Dexmedetomidine hydrochloride as a long-term sedative
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Dexmedetomidine hydrochloride as a long-term sedative
Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory system. Dexmedetomidine infusions lasting more than 24 hours have not been approved since the first approval was acquired in the US in 1999. However, in 2008, dexmedetomidine infusions for prolonged use were approved in Colombia and in the Dominican Republic, and the...
متن کاملDexmedetomidine: a novel sedative-analgesic agent.
Since the first report of clonidine, an alpha2-adrenoceptor agonist, the indications for this class of drugs have continued to expand. In December 1999, dexmedetomidine was approved as the most recent agent in this group and was introduced into clinical practice as a short-term sedative (<24 hours). Alpha2-adrenoceptor agonists have several beneficial actions during the perioperative period. Th...
متن کاملHigh dose dexmedetomidine as the sole sedative for pediatric MRI.
OBJECTIVE This large-scale retrospective review evaluates the sedation profile of dexmedetomidine. AIM To determine the hemodynamic responses, efficacy and adverse events associated with the use of high dose dexmedetomidine as the sole sedative for magnetic resonance imaging (MRI) studies. BACKGROUND Dexmedetomidine has been used at our institution since 2005 to provide sedation for pediatr...
متن کاملIntranasal Dexmedetomidine as a Sedative Premedication for Patients Undergoing Suspension Laryngoscopy: A Randomized Double-Blind Study
BACKGROUND Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable perioperative anxiolysis in children. We investigate intranasal dexmedetomidine as a sedative premedication for anesthesia recovery in an adult population. METHODS A prospective randomized controlled trial; 81 adult patients scheduled for elective suspension laryngosco...
متن کاملDexmedetomidine as a Sedative Agent in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials
INTRODUCTION The effect of dexmedetomidine on length of intensive care unit (ICU) stay and time to extubation is still unclear. MATERIALS AND METHODS Pertinent studies were independently searched in BioMedCentral, PubMed, Embase, and the Cochrane Central Register of clinical trials (updated February first 2013). Randomized studies (dexmedetomidine versus any comparator) were included if inclu...
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ژورنال
عنوان ژورنال: Therapeutics and Clinical Risk Management
سال: 2011
ISSN: 1178-203X
DOI: 10.2147/tcrm.s14581